Key Opinion Leader

Dr. Neil Singla is a nationally recognized key opinion leader in analgesic protocol design and implementation. He has published extensively and is a frequent lecturer for physicians, pharmaceutical companies and medical research institutes throughout the country. For the past several years, the main focus of Dr. Singla's academic endeavors has been to analyze and understand how the inherent variability in subjective endpoint clinical trials can be minimized. He has developed novel techniques for patient education designed to minimize variability, reduce placebo response and increase effect size.

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Reducing Variability/Placebo Response

The properly educated patient can be your greatest ally in producing a positive analgesic clinical trial. A significant portion of an analgesic investigation's variability is produced secondary to cognitive gaps that the patient may have when interpreting the various protocol mandated scales and questions... Read more

Placebo Response Education

Lotus has developed a proprietary placebo response video education series designed to modulate patient expectations and dampen placebo response.

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Phase 1 and Analgesic Proof-of-Concept

Lotus' patient training tools and data collection methodologies result in reduced variability and improved statistical sensitivity towards the primary efficacy endpoint.

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Analgesic Study Experience

Lotus Clinical Research has extensive experience with the following pain models:

Acute Pain

Soft Tissue

  • Hysterectomy
  • Hernia Repair
  • Laparoscopic
  • Hemorrhoidectomy


  • Colon Surgery
  • Abdominoplasty
  • Keloid Removal
  • Liposculpture
  • Tubal Ligation


  • Bunionectomy
  • Total Hip Replacement
  • Total Knee


  • Dental Pain
  • Shoulder / Knee Arthroscopy
  • Hip / Knee Arthroscopy

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Chronic Pain


  • Diabetic Peripheral
  • Radicular Low
    Back Pain
  • Post-Herpetic


  • Non-Radicular Low
    Back Pain
  • Fibromyalgia
  • Osteoarthritis
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Lotus has successfully conducted over 100 clinical trials and has played a significant role in numerous analgesic approvals in the recent past...Read more

Learn more about our numerous analgesic approvals


Lotus is known world-wide as a top-enrolling center for all types of analgesic research studies. We have the world's largest analgesic clinical trial database with over 12,000 potential study volunteers. Our database has been accrued over the past 13 years utilizing nearly $5 million dollars in cumulative advertising funds. The database is sortable by multiple factors including specific analgesic disease state (low back pain vs. neuropathic pain, etc.) and daily morphine mEq consumption. It is lovingly maintained, sorted and pruned to yield excellent enrollment results.

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