Aug. 1, 2010

Efficacy and tolerability of intranasal ketorolac (SPRIX) was assessed in abdominal surgery patients.


Adult patients were randomly assigned to receive ketorolac 31.5 mg (n ¼ 214) or placebo (n ¼ 107) every 6 hr after surgery for 48 hr, then up to 4 times/day for up to 5 days.

Morphine sulfate via patient controlled analgesia was available in both groups as needed.

Effective management of acute postoperative pain often involves a multimodal approach incorporating the use of nonopioid analgesics in order to optimize analgesic efficacy and reduce opioid-related side effects. Nonopioid analgesics are often preferred in ambulatory surgeries to allow patients to return to normal functioning more quickly. Ketorolac is a nonopioid, balanced COX1/2 inhibitor used for the short-term management of moderate-to-severe acute pain in patients undergoing inpatient and ambulatory procedures.

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