Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters after Single-Dose Administration of Intravenous, Oral or Rectal Acetaminophen

Nov. 17, 2011

Intravenous (IV) acetaminophen was FDA-approved in November 2010 for the treatment of acute pain and fever in adults and children ≥ 2 years.

In an IRBapproved,single site study conducted by Singla, 6 healthy adult males were given IV, oral (PO) or rectal (PR) acetaminophen in a 3-way crossover design.

A spinal catheter was placed for cerebrospinal fluid (CSF) sampling. The objective was to show comparative plasma and CSF concentration-time curves in healthy adult males after IV, PO, or PR acetaminophen.

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Plasma and CSF Parameters

Intravenous (IV) acetaminophen was FDA-approved in November 2010 for the treatment of acute pain and fever in adults and children ≥ 2 years.