Sep. 7, 2011

TD-1211 Demonstrates Peripheral Selectivity and Constipation-Relieving Effects in Patients with Opioid-Induced Constipation


Opioid analgesics such as morphine continue to play a critical role in chronic cancer and non-cancer pain control. Despite their effectiveness, opioids have significant drawbacks, notably the development of analgesic tolerance and physical dependence, sedation, respiratory depression and bowel dysfunction.

Opioid-induced constipation (OIC) is common, affecting more than 50% of patients receiving chronic morphine treatment for cancer pain and, unlike the majority of opioid-induced effects, is not prone to tolerance.
Consisting of constipation, delayed gastric emptying, abdominal discomfort, and nausea, OIC can be debilitating in patients.

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