Oct. 16, 2010

Pregabalin is an alpha‐2‐delta receptor modulator of voltage‐gated calcium channels


It is indicated in the US for the treatment of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia in addition to fibromyalgia.

It is not currently approved for the treatment of postoperative pain

The studies were intended to support potential registration in the US

The efficacy and safety of pregabalin in the treatment of post‐surgical pain were evaluated in 2 separate clinical trials: – Post‐total knee arthroplasty (post‐TKA) ClinicalTrials.gov
identifier: NCT00442546, Post‐inguinal hernia repair (post‐IHR) ClinicalTrials.gov identifier: NCT00551135

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