• Abdominoplasty


    Most analgesic programs require an experiment that demonstrates drug efficacy in soft tissue surgery. While the bunionectomy is the gold standard for acute pain experiments in boney surgery, for many years there was no soft tissue equivalent to a bunionectomy.
    Discover More
  • Bunionectomy


    Bunionectomy is a highly standardized, rapidly recruiting boney pain model.   As a CRO and research site, Lotus Clinical Research is nationally recognized for its experience and proficiency in bunionectomy research. For bunionectomy trials, Lotus Clinical Research provides both site..
    Discover More
  • Delayed Onset Muscle Soreness

    Delayed Onset Muscle Soreness

    Delayed Onset Muscle Soreness (DOMS) is an acute pain state that arises 24-48 hours after unaccustomed or eccentric exercise. As an analgesic model, it is well suited for testing topical over-the-counter or prescription analgesics. Lotus Clinical Research has performed several..
    Discover More
  • Joint Replacement Surgery

    Joint Replacement Surgery

    Total Knee Replacement and Total Hip Replacement - Lotus Clinical Research has extensive experience in the joint replacement model both as a CRO and as a research site. We can perform single-center joint replacement studies within our own walls, and..
    Discover More
  • Laparoscopic & Non-Laparoscopic

    Laparoscopic & Non-Laparoscopic

    Laparoscopic and Non-Laparoscopic Surgeries - Lotus Clinical Research has extensive experience both as a site and CRO in the following soft tissue surgical models: Herniorrhaphy (open and laparoscopic) Hysterectomy (open and laparoscopic) Colon surgery (open and laparoscopic) Bariatric surgery Laparoscopic..
    Discover More
  • Third Molar Extraction

    Third Molar Extraction

    Dental - Of all the acute pain models one can choose from, dental pain has been shown to have the greatest assay sensitivity, fastest recruitment, and the lowest cost. Lotus Clinical Research is an ideal choice for dental pain (third..
    Discover More
  • Postoperative Nausea and Vomiting (PONV)

    Postoperative Nausea and Vomiting (PONV)

    The conduct of PONV clinical trials has significant impact on their assay sensitivity. This is in part due to the strict experimental controls needed to demonstrate an effect in PONV, which are sometimes contrary to standard clinical practice. Rescue vs...
    Discover More

Placebo Response Mitigation

Learn More

Lotus Clinical Research has developed proprietary materials for patient education and staff training that consistently increase effect size by minimizing variability and placebo response in analgesic clinical trials. In addition, we provide an exclusive placebo response education series designed to modulate patient expectations and mitigate placebo response.