Acute Pain

Bunionectomy is a highly standardized, rapidly recruiting boney pain model.   As a CRO and research site, Lotus Clinical Research is nationally recognized for its experience and proficiency in bunionectomy research. For bunionectomy trials, Lotus Clinical Research provides both site..

Delayed Onset Muscle Soreness (DOMS) is an acute pain state that arises 24-48 hours after unaccustomed or eccentric exercise. As an analgesic model, it is well suited for testing topical over-the-counter or prescription analgesics. Lotus Clinical Research has performed several..

Total Knee Replacement and Total Hip Replacement - Lotus Clinical Research has extensive experience in the joint replacement model both as a CRO and as a research site. We can perform single-center joint replacement studies within our own walls, and..

Laparoscopic and Non-Laparoscopic Surgeries - Lotus Clinical Research has extensive experience both as a site and CRO in the following soft tissue surgical models: Herniorrhaphy (open and laparoscopic) Hysterectomy (open and laparoscopic) Colon surgery (open and laparoscopic) Bariatric surgery Laparoscopic..

Dental - Of all the acute pain models one can choose from, dental pain has been shown to have the greatest assay sensitivity, fastest recruitment, and the lowest cost. Lotus Clinical Research is an ideal choice for dental pain (third..

The conduct of PONV clinical trials has significant impact on their assay sensitivity. This is in part due to the strict experimental controls needed to demonstrate an effect in PONV, which are sometimes contrary to standard clinical practice. Rescue vs...