Delayed Onset Muscle Soreness

Delayed Onset Muscle Soreness (DOMS) is an acute pain state that arises 24-48 hours after unaccustomed or eccentric exercise. As an analgesic model, it is well suited for testing topical over-the-counter or prescription analgesics.

Lotus Clinical Research has performed several large-scale studies (operating as both a site and the CRO) in the DOMS model. Dr. Singla has also published a methodological review article in PAIN concerning experimental best practices for DOMS.

Enrollment

Average enrollment is 40 subjects per month at the Lotus Clinical Research site. Screen failure rates are similar to a healthy volunteer population, but may be slightly higher due to activity restrictions specific to recruitment of the DOMS population