Reducing Placebo Response in Analgesic Clinical Trials
In analgesic clinical trials, managing placebo response can make the difference between a successful study and a false negative outcome. Lotus Clinical Research has developed a proprietary placebo response mitigation toolkit with subject and investigator training materials designed to reduce placebo response and minimize the chance of false negative trial results.
The following videos on placebo response may be of interest to you:
- Subject Education and Placebo Response Mitigation Video (5 minutes)
- Webinar on Mitigation of Placebo Response Phenomenon in Analgesic Clinical Trials (20 minutes)
Lotus Clinical Research’s patient education and staff training materials consistently increase effect size by minimizing variability and placebo response in analgesic clinical trials. The video education series is designed to modulate patient expectations and dampen placebo response by providing patients with important information about an analgesic trial’s purpose, as well as what to expect throughout the duration of a study.
Through this series, patients receive placebo response education across the following areas:
- Understanding the terms placebo control and double-blind
- What is the placebo effect?
- The difference between a treatment relationship and a research relationship
- How to rate your pain consistently using pain scales
- Measuring pain on a Visual Analog Scale (VAS)
- Numerical Pain Rating Scale (NPRS)
- Collecting pain relief assessments
- Measuring pain relief using the two-stopwatch technique
- What is rescue medication
